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The presence of gross nodularity is strong evidence against Hashimoto's thyroiditis, but differentiation on this basis is not infallible

Literature search was conducted on PubMed, Scopus, Web of Science, and Embase using a combination of the keywords gut microbiota, gut microbiome, gut-brain axis, gut-kidney axis, gut-brain-kidney axis, chronic kidney disease, dysbiosis, therapy, metabolites, and neuroinflammation. Relevant studies were selected and synthesized in this narrative review

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First-ever ischemic stroke and increased risk of incident heart disease in older adults